Easier to recover from on GLP-1 drugs: Moderate-intensity resistance training with controlled tempo (3-second eccentric) Lower total volume sessions (8 to 12 working sets) Walking and low-intensity steady-state cardio Mobility and flexibility work Harder to recover from on GLP-1 drugs: High-volume bodybuilding-style sessions (20+ sets) High-intensity interval training (HIIT) Heavy eccentric-focused training (slow negatives, drop sets) Two-a-day training sessions Endurance workouts over 60 minutes at moderate-to-high intensity The common thread: anything that creates significant muscle damage or glycogen depletion will take longer to recover from when calories are restricted
Additionally excluded are studies conducted on individuals who are on systemic anti-inflammatory or immunosuppressive drugs, or who have active inflammatory conditions (such as rheumatoid arthritis or acute infections)
Until Phase II and III results emerge with proper endpoints (mucosal healing rates, histologic remission, patient-reported outcomes), the evidence base will remain preclinical
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