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Cutting-Edge: preclinical and clinical development of the first approved Lag-3 inhibitor
Although drugs like atorvastatin may reduce mitochondrial biogenesis and ATP production in muscles, a 12-week combined moderate-intensity endurance and resistance training program can enhance citrate synthase activity, promote capillary density, and increase the proportion of type I muscle fibers in statin users, thereby counteracting these adverse effects (Macchi et al., 2022b