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Dose-dependent effect for oral semaglutide was assessed and proven in Japanese PIONEER 9 trial, where greater reduction of HbA1c and weight loss was achieved with higher dose of oral semaglutide compared to placebo and 0.9 mg liraglutide (46)

Since bacteriophage predator-prey dynamics regulate the diversity and equilibrium of the bacterial microbiome (221), alterations in the virome can also cause intestinal microbial dysbiosis in different diseases (222224) and alter microbiome homeostasis

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doi: 10.3906/sag-2104-188 221 GardnerDKKuramotoTTanakaMMitzumotoSMontagMYoshidaA

Aerobic exercise training may improve nerve function in type 2 diabetes and pre-diabetes: a systematic review