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Nevertheless, the data presented here overall extend the importance of HPX and heme clearance from biological fluids, including plasma, and implicate a previously unanticipated and potentially key role for the HPX system in the regulation of many aspects of heme-linked iron homeostasis in health and disease

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Additionally, higher levels of total cholesterol, LDL, triglycerides, and lower HDL were observed in the responsive group, suggesting greater insulin resistance [15]