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In your stomach, it slows gastric emptying, meaning food stays in your digestive system longer, extending satiety

Mitochondrial capacity varies between individuals based on genetics, conditioning, age, comorbidities, and metabolic health

Semaglutide clears in approximately 45 weeks due to its 7-day half-life, while tirzepatide clears in 34 weeks with a 5-day half-life

Tolerance and dose adjustment over time Some people report decreasing effectiveness at a given dose after 6-12 months

Heart-rate changes can have multiple causes and do not identify one receptor