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In the STEP 1 trial, adults taking weekly semaglutide (the same drug in Ozempic and Wegovy) lost an average of 14.9% of their body weight over 68 weeks , compared to only 2.4% in the placebo group

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GIPR Gene Variants and Dual-Action Drug Response The GIPR rs1800437 variant influences glucose-dependent insulinotropic polypeptide signaling, a pathway that tirzepatide activates but semaglutide does not

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