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In addition, brain insulin resistance affects tau metabolism and promotes the hyperphosphorylation of tau proteins, tau protein aggregation, the formation of paired helical filaments, and the further formation of NFTs (Mohandas et al., 2009)

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Furthermore, genes critical for peroxisome biogenesis ( Pex3 , -69%) and mitochondrial membrane integrity ( Crls1 , -89%) were significantly suppressed