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Freezing causes ice crystal formation that physically disrupts the molecular structure, making the medication potentially unsafe to use

We may try spreading out the number of days between doses from weekly to, say, every 10 days

In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids. Incretin hormones are released whenever food is consumed

doi:10.3390/ijms23020739 Yaribeygi H, Maleki M, Jamialahmadi T, et al

Final calorie targets, medication use, and bariatric eligibility are determined by a licensed healthcare provider based on full clinical assessment

Alternatively, if your nausea is mild and manageable, morning injection allows you to experience the peak during active hours when physical movement and distraction naturally reduce nausea perception