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In terms of patients diagnosed with idiopathic generalized epilepsy or unclassifiable seizures, VPA remains also the candidate while lamotrigine and topiramate should not be considered in these patients due to lower efficacy and intolerable profiles [158]

In advanced cancer, the high expression of GPX3 clears excess ROS in the extracellular environment, maintaining the redox homeostasis in the TME, protecting tumor cells and enhancing drug resistance (88)

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Biomedicines (2021) 9:1927

Genes controlling cysteine metabolismsuch as those regulating transsulfuration pathwaysaffect glutathione precursor availability