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This decline impairs mitochondrial function and sirtuin activity and increases chronic inflammation

Oral precursors (NMN/NR) are the most accessible route

Clapper et al ., 1990)

Therefore, these animal models may not fully recapitulate the complexity of human NAFLD, limiting the translational relevance of the findings

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Ferroptosis and polycystic kidney disease Autosomal dominant polycystic kidney disease (ADPKD) is one of the causes of end-stage renal disease and is caused by a polycystic protein-1 (PKD1) or PKD2 gene mutation