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Treating the metabolic conditions becomes part of treating the osteoarthritis. Research has shown that patients with type 2 diabetes are more likely to have severe osteoarthritis as well as a higher likelihood of needing revision surgeries after knee replacements

Patients with a personal or family history of Multiple Endocrine Neoplasia (MEN) syndrome or thyroid cancer should not use this medication

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Hyperglycemia is associated with excessive ROS formation in mitochondria, as documented by increased DNA strand breaks

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