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Beyond its canonical role in glycolysis, GAPDH is known for its redox sensitivity, involvement in mitochondrial dysfunction, and even antiviral activity through interactions with the SARS-CoV-2 spike protein 56,57,58

Bouet PE, El Hachem H, Monceau E, et al

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Consequently, in vitro experiments confirmed that AA-CDs effectively inhibit chondrocyte ferroptosis, consequently mitigating the degradation of the extracellular matrix (ECM)