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Eck HP, Gander H, Hartmann M, et al

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She sometimes prescribes experimental peptides as an additional treatment, while making their uncertainty clear

Response to stress Activation of CRF signaling CRF expression is upregulated in the hypothalamus and the peptide released into the median eminence under conditions of stress leading to pituitary ACTH and subsequently adrenal glucocorticoid hormone release (cortisol in humans and corticosterone in rodents) (Turnbull and Rivier, 1997