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When these molecules outnumber antioxidants, the body enters a state of oxidative stress

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Bifidobacteria are important immunomodulators that modulate immune responses through multiple pathways, enhancing gut barrier function by upregulating suppressive Foxp3+ Tregs and inhibiting immune responses triggered by Th2 and Th17 cells 89

The three states within the model are considered adaptive rather than pathological, as they evolved to meet the specific survival needs of different species 2m15s