Published in the New England Journal of Medicine in 2025, this Phase 3 study enrolled 610 Chinese adults with obesity or overweight accompanied by at least one weight-related comorbidity
To put it in context, the standard dose of semaglutide the active ingredient in Ozempic and Wegovy starts at 0.25 milligrams once a week
The STEP 1 trial published results in the New England Journal of Medicine in February 2021, showing 14.9% weight loss at 68 weeks (Wilding et al., NEJM 2021)
Rapid weight loss can result in losing 1525% of lean muscle if resistance training and adequate protein intake arent part of the plan
Priority was given to recent publications and high-quality evidence, with emphasis on studies published after 2022 reflecting the evolving understanding of perioperative risks
Each dose of GLP-1s is given weekly, which means that you can expect a little time between injections and results being seen