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Cardiovascular Considerations PT-141 can cause transient increases in blood pressure and heart rate, with mean increases of 3-10 mmHg systolic and 2-5 mmHg diastolic pressure observed in clinical trials

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Limited case reports of accidental first-trimester exposure did not report severe adverse outcomes, but extended use carries greater theoretical risk

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In topical application, studies use concentrations of 0.01-1% in cream or serum formulations (Pickart et al., BioMed Res Int 2015For subcutaneous injection (research), doses vary depending on the experimental model