When the mutase enzyme is impaired, methyl malonic acid (MMA) accumulates
DIA-based phosphoproteomics achieves an order of magnitude broader dynamic range, higher reproducibility of identification, and improved sensitivity and accuracy of quantification compared to state-of-the-art data-dependent acquisition (DDA)-based phosphoproteomics
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Further complementary studies by Skosnik, PD demonstrated a doubling of the theta power amplitude of the electroencephalogram (EEG) in patients with major depressive disorder after a single oral dose of psilocybin for 14 days [38]