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Sci Rep 12:8764

Methylcobalamin B12 is also indicated in those with pernicious anemia, diabetes, neuropathy, heart disease, circadian rhythm sleep disorders, memory loss, depression, fatigue, AIDS, inflammatory bowel disease (IBD), Lyme disease, osteoporosis, tendonitis, psychiatric disorders, Alzheimers disease, liver and kidney disease, and asthma

The FDA does not require pre-approval for cosmetic ingredients, which is why thousands of serums, creams, and prescription formulations contain it without regulatory issue

Msheik Z, El Massry M, Rovini A et al (2022) The macrophage: a key player in the pathophysiology of peripheral neuropathies

Older literature with high risk of bias

These tumors have not been reported in humans, but rodent studies have shown evidence of thyroid tumors, including thyroid cancer