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It can reduce inflammation and oxidative stress, both key contributors to heart disease

doi:10.1016/S2213-8587(22)00187-5 91

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It provides broader context for Dihexa's mechanism of action and its position within the angiotensin IV receptor research field, evaluating both the strength and limitations of the existing preclinical evidence base

Despite the guideline-recommended use of both SGLT2i and GLP-1RA therapy, there is a paucity of real-world evidence on the long-term effects of combining SGLT2is with newer generation GLP-1RAs (including once-weekly GLP-1RAs, once-daily oral semaglutide, and dual GLP-1/glucose-dependent insulinotropic polypeptide [GIP] agonists) on metabolic outcomes and other cardiorenal outcomes [22]

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