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Additionally, SGLT2i can lower HbA1c levels by 0.5-1.0% and support weight loss ( Studies have indicated that increased expression of the sodium-hydrogen exchanger isoform 1 (NHE-1) is linked to heart failure and may contribute to the development of hypertrophy and cardiac injury during ischemia and reperfusion ( Of note, long-term use of SGLT2i may lead to a reduction in glycosuric efficacy, without a corresponding decline in cardiovascular benefits
Patients frequently experience improved insulin sensitivity, better glucose regulation, and decreased insulin resistance
PubMed, Hidayat, K., et al
You can stay at the lower dose longer if you need time to adjust
Nausea, diarrhea, vomiting, and constipation commonly occur within the first month of starting.[ref][ref] Note that for many people, gastrointestinal side effects seem to be dose-related
The most common are nausea, diarrhoea, vomiting, and constipation, with dysesthesia and a temporary rise in resting heart rate less common
