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The mechanism relevant to eating behaviour involves both peripheral and central pathways

Concentrations are five to ten times higher in hepatocytes than other cells as the liver is constantly processing and removing toxins

In elaboration of these observations, work in an alpha-cell-specific PC1/3 knockout mouse model demonstrates that the loss of alpha-cell GLP-1 production impairs glucose homeostasis and GSIS in metabolically stressed mice but not in chow-fed mice (19)

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Vutiglabridin mitigates the weight-loss plateau under calorie-restriction conditions To evaluate its anti-obesity efficacy, DIO mice were treated for 3 weeks with 50 mg/kg Vutiglabridin, a dose effective in a previous study [24]