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300 L diluted PMNs were pre-incubated with vehicle (DMSO), Zileuton (an inhibitor of 5-LOX), and GPX4 activator at 37C for 15 min, respectively

Efficacy data show HbA1c reductions of 1.02.0% and weight loss of 1020% body weight, with superior CV risk reduction versus older therapies

Limited evidence suggests only modest effects in specific populations, with results highly variable and often reversible upon discontinuation

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Feng X, Li X, Liu N, Hou N, Sun X, Liu Y