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Substantial or rapid weight loss can increase the risk of cholelithiasis

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[DOI] [PubMed] [Google Scholar] 81.Park IJ, Lee YK, Hwang JT, Kwon DY, Ha J, Park OJ

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It was reported that BMAL1 deficient mice had altered circadian rhythm of circulating IGF-1 levels (Patel et al., 2016), and CRY1 and 2 deficient mice had reduced IGF-1 production ( Due to the difficulty in measuring pulsatile GH secretion, the interaction between the GH-IGF-1 axis and circadian clock warrants further detailed research