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controlled melanogenesis observation

[PubMed ID: 19085093]

This stand-up activation model fits well with the general framework of the two domain mechanism for ligand binding and receptor activation of class B GPCRs, where the ECD serves as an affinity trap to interact with the C-terminal portion of peptide hormones, allowing the N-terminus of peptide hormones to insert into the TMD to activate the receptor [19, 20, 2326]