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Rather than being associated with a single mechanism, the peptide appears to interact with multiple signaling pathways that influence how tissues respond to stress and structural disruption

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Angiotensinogen (Ag), the precursor of angiotensin peptides, is cleaved to generate angiotensin II (Ang II), which is significantly elevated in heatstroke patients and animal models, accompanied by reduced angiotensin-(17) [Ang-(17)] levels [26, 37]

Patent EP 1 934 235