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BPC-157 has demonstrated regenerative effects on bone tissue and has the potential to promote bone healing and mineralization, ultimately aiding in the restoration of calcium balance

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Similarly, the protective effects of metformin on subchondral bone are indirect, occuring through cartilage integrity preservation and oxidative stress reduction 54

Electrostatic similarity analysis Electrostatic similarity calculations were performed using OpenEye toolkit by combining ROCS for shape-based alignment and EON for electrostatic similarity calculations

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