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1 Within the model, the annual probability of major diabetes-related macrovascular complications is derived from risk equations based on the UK Prospective Diabetes Studies 68 and 82, Swedish National Diabetes Registry, and Australian Fremantle Diabetes Study, providing more choice than previous CADTH reports

Most commercially successful GLP-1 therapies continue to be administered through injectable formulations

Part of this comes from weight loss itself (excess adipose tissue actively produces inflammatory signals), and part appears to come from tirzepatides direct metabolic effects

but not yet approved as a sweetener in Canada

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