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Understanding Hyperpigmentation Hyperpigmentation occurs when certain areas of the skin become darker than the surrounding areas, often caused by sun exposure, hormonal changes, or skin injuries

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The underlying mechanism involves radiotherapy increasing the expression of interferon regulatory factor (IRF) 1 by activating the interferon signaling pathway

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They are often paired because CJC-1295 provides GHRH-receptor signaling while Ipamorelin provides GHSR/ghrelin-receptor signaling