The IL-1 signaling pathway is implicated in acute doxorubicin-induced cardiotoxicity, with increased expression of IL-1, IL-1Ra, and IL-1RI correlating with cardiac damage [87]
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Amylin, an anorexic neuroendocrine hormone co-secreted with insulin, is deficient in individuals with diabetes and plays an important role in postprandial glucose homeostasis, with additional potential cardiovascular and neuroprotective functions
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The metal chelating capacity was significant as it reduced the concentration of the catalyzing transition metal in lipid peroxidation