doi: 10.1210/endrev/bnaa026 68
As food intake and body weight are controlled by the central nervous system (CNS), understanding the complex CNS mechanisms that regulate energy homeostasis is essential for the discovery of successful antiobesity therapeutics
Each comparison involves tradeoffs between price, efficacy, side effect profiles, and availability that researchers should evaluate based on their specific protocol requirements and budget constraints
As we look ahead, the integration of peptide therapies like cagrilintide into clinical practice will likely continue to grow
This distinction matters because pulsatile GH secretion maintains receptor sensitivity, while continuous exogenous GH leads to receptor downregulation and metabolic dysfunction over time
Eva Hjkov, MPH, MBA , a specialist in preventive, functional medicine and nutrition