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The label for Wegovy includes a warning of the risk of hip fracture: More fractures of the hip and pelvis were reported on WEGOVY than on placebo in female patients: 1% (24/2448) vs

Discontinuation and weight regain How often people stop the medication TRIUMPH-4 (n=445, 68 weeks, obesity with knee osteoarthritis): 18.2% on 12 mg, 12.2% on 9 mg, 4% on placebo 2 TRANSCEND-T2D-1 (n=537, 40 weeks, type 2 diabetes): 5.1% on 12 mg, 4.5% on 9 mg, 0% on placebo 3 Phase 2 (n=338, 48 weeks): 6 to 16% across doses, 1% on placebo 1 For comparison, Wegovys STEP-1 trial reported a discontinuation rate of around 7% due to side effects, and Mounjaros SURMOUNT-1 reported a similar rate

The program uses GLP-1 medications like Semaglutide and Tirzepatide , both known for their ability to improve metabolic health and promote steady fat reduction

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Interestingly, studies have found that in hospitalized patients, elevated vitamin B 12 levels were predictive of short, medium, and long-term mortality at six, 12, and 48 months (26)

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