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J Am Heart Assoc

Trimethylamine N-oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-B

For example, E50K mutated OPTN induced impairment of autophagy that led to cell death in RGC-5 cell lines 28 , and rapamycin, an autophagic inducer, protected RGCs in E50K OPTN overexpressed rats in vivo 29

However, it is important to mention that the studies included doses of CoQ 10 that varied from 20 to 200 mg per day