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Effectiveness of triple therapy with dapagliflozin add-on to dual therapy over 52 weeks in patients with uncontrolled type 2 diabetes mellitus in a centre of high complexity, Cali-Colombia

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These phosphorylated tyrosines serve as docking sites for adaptor proteins including insulin receptor substrate-1 (IRS-1), insulin receptor substrate-2 (IRS-2), and Shc, which are recruited to the activated receptor and themselves become phosphorylated, initiating multiple downstream signaling cascades

The conversion of ribonucleotides to deoxyribonucleotides, through the action of ribonucleotide reductase, requires NADPH, therefore any rapidly proliferating cell needs large quantities of NADPH

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