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PubMed , Brain Sciences , vol
Dihydroorotate dehydrogenase (DHODH) is a critical enzyme that converts dihydroorotate (DHO) to orotate while reducing CoQ to CoQH 2 [84, 85]
doi: 10.1182/blood-2015-02-631044
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Melatonin can reduce the action of PGE-2, allowing the secretion of IL-2, stimulating at the same time Th1 lymphocytes and monocytes to increase the release of other cytokines, such as IL-6, IL-12, IL-27, and TNF-, also regulators of NK cell proliferation [33,48]
