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SURMOUNT-OSA (reduction in apnoeahypopnea in obstructive sleep apnoea) Survodutide : MASH trial (resolution of MASH, improvement in fibrosis) Another key event in 2024 was the readout of the first head-to-head trial in obesity, Lillys SURMOUNT-5, pitting tirzepatide against semaglutide, with the former demonstrating superior weight loss

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Further research is needed to establish a comprehensive understanding of DSIPs safety profile and to provide clear guidelines for its responsible use

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Neither trial reported adverse effects