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Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine

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After 1-6 h, the drug was removed by washing the cultures in complete RPMI culture medium (4 x 200 L)

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This randomized phase 2a #ClinicalTrial demonstrates that TPN171H, a potent and selective PDE5 inhibitor, significantly reduces pulmonary vascular resistance and improves acute hemodynamics in patients with #PulmonaryArterialHypertension (PAH), establishing it as a promising and well-tolerated oral therapeutic candidate for managing PAH

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Biology and management of patients with triple-negative breast cancer

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Neurology 49 , 229239 (1997)

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