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Due to the high expression profile of GLP-1R in pancreatic -cells, GLP-1 analogs (such as exendin-4) have been modified by different methods (to prolong half-life, maintain receptor binding affinity and reduce renal drug accumulation) for theranostic purposes and serve as excellent templates for future cardiovascular drug development[178-184]

Rybelsus is a GLP-1 semaglutide tablet for type 2 diabetes, with a lower maintenance dose and different dosage schedule than Wegovy tablets

The catch: being overweight alone probably will not qualify

10.1210/jc.2010-2081 16 BradleyD

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Semaglutide targets GLP-1 only, while tirzepatide targets GLP-1 and GIP