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This usually occurs in individuals with underlying digestive conditions, those who have trouble absorbing all nutrients through digestion, or those with pernicious anemia, which specifically prevents B12 absorption
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Inhibition of methylation of MBP has been shown to cause demyelination, further emphasizing the importance of this process in maintaining the structure and function of myelin [73], (Fig
When B12 levels become problematic: High-dose supplementation (particularly doses exceeding 1,000 micrograms daily) Frequent B12 injections without medical supervision Underlying conditions affecting B12 metabolism Concurrent use of multiple B12-containing supplements The NHS does not set an upper safe limit for vitamin B12 because harmful effects from excessive intake have not been definitively established
The answer can be unclear, especially if you have a supply
