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Consistent findings have shown that GLP-1R agonism promotes weight loss and improves glucose homeostasis in rodents, monkeys and humans (reviewed in Barrera et al., The anatomical distribution of the endogenous GLP-1 system GLP-1 is derived from the preproglucagon gene

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I do not take a GLP-1 myself but have worked with hundreds of people who have

The timing of GLP-1 administration may influence the tolerability of these symptoms, though this has not been definitively established in clinical trials

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