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[1] Downstream Effects on Bone and Mineral Metabolism Elevated GH and IGF-1 have direct effects on the kidney, bone, and gut that overlap with vitamin D's own signaling pathways

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Pupils, color vision, and contrast sensitivity testing were all normal or unremarkable

Other side effects can include fatigue, headache, hair loss, vomiting and burping

HMB for Muscle Retention During Weight Loss In dieters, 3 g/day HMB maintained 70-80% more lean mass over 8 weeks compared to placebo, critical for those on GLP-1s who face accelerated catabolism

This can be caused by malnutrition, decreased absorption of thiamine by the gastrointestinal tract, a reduction in stored thiamine due to liver disease, or a combination of these factors