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EJHG 82 MeyerT.CooperJ.RaspeH
the clinical relevance of this finding in humans is unknown, and in UK and EU prescribing information this is noted as a precaution rather than a formal contraindication but individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) should discuss this with their doctor
DNA methylation is one of the key epigenetic mechanisms for regulation of gene expression which is currently a subject of intensive research and it was reported that maternal deficiency of folate and B 12 could result in aberrant gene expression with consequential health outcomes (Reference Irwin, Pentieva and Cassidy126,Reference Monasso, Hoang and Mancano127)
BMC Cardiovasc Disord, 2014, 14, 88
Microdosing weight loss drugs can be a smart move if done with care and overseen by a medical professional, especially for those who are sensitive to side effects or dont need aggressive weight loss