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When insulin is ineffective, more glucose winds up floating around in your blood, which prompts your pancreas to overcompensate and produce even more insulin, Dr

The SURMOUNT-1 trial tested the ability of tirzepatide to produce weight loss in people with obesity who do not have diabetes

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The study also found that tirzepatide reduces the risk of ventricular arrhythmia in LPS-treated mice [60]

Similarly, the actions of GLP-1 on inhibition of gastric emptying are also preserved in subjects with poorly controlled type 2 diabetes