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5.1 Anti-inflammatory and anti-nociceptive effects Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) play distinct roles in inflammation, with omega-3 PUFAs generally exhibiting anti-inflammatory effects and omega-6 PUFAs tending towards pro-inflammatory actions, through competitive metabolic processes

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doi: 10.3389/fphar.2022.944088 35

The mechanism and timeline are the same as for male patients, with some adjustments in the protocol for patients in perimenopause or menopause where hormonal changes affect collagen synthesis and healing rates

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PURINERGIC SIGNALING AND PLATELET ACTIVATION Purinergic signaling is an important link among platelet activation, vascular thrombosis, and inflammation ( Figure 2 )