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In published preclinical work, KPV has been studied for inhibiting NF-B activation in intestinal epithelial cells, with one widely cited study showing PepT1-mediated transport into colonic cells as part of its anti-inflammatory mechanism in mouse colitis models (Dalmasso et al., Gastroenterology , 2008)
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In summary, while the therapeutic benefits of GLP-1RAs in managing T2DM are indubitable, our findings serve as a call for healthcare professionals to balance efficacy with safety judiciously
We hypothesized that the topical delivery of liquid NAC via oral rinses may provide localized neuroprotective and mucosal-stabilizing effects, resulting in symptom relief and improved oral health-related quality of life
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