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Notably, subjects carrying MC1R variant alleles who typically tan poorly and are at higher skin cancer risk showed a greater melanin response than those with wild-type MC1R (Fitzgerald et al., 2006)

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Despite these benefits, our findings also suggest an increased risk of ketosis in individuals with T1DM treated with GLP-1 RAs 26

These patterns suggest insufficient monitoring and lack of timely dose adjustment following GLP-1RA initiation, potentially leading to thyroid hormone over-replacement

Weatherall's role is to present the clinical risks and benefits clearly, supporting each family in reaching the decision that best fits their child