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Inhibition of the target gene expression can occur through various mechanisms such as RNA interference, once the sense-antisense mRNA duplex has formed, transcriptional interference, in which the NAT can act as a physical barrier for RNA polymerase activity, or epigenetic methylation of the sense gene DNA, thus inhibiting the transcription of the sense mRNA transcript [55, 56]

Floyd RA

Formulation in sucrose can increase aggregation over time because of protein glycation when sucrose is hydrolyzed (58)

Smaller infarcts preserve more functional tissue, which translates to better pumping ability and improved long-term outcomes

The presence of copper may be central to these observations, including collagen synthesis, modulation of inflammatory signaling, and antioxidant potential

Shaking creates strong mechanical forces that can physically damage or denature the delicate peptide structures