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Above certain plasma concentrations, arginase activity increases to compensate, further limiting how much arginine stays available for NOS
197 For instance, increased blood urea concentrations can alter the microbiome, resulting in the increased generation of toxic metabolites from the gastrointestinal tract as well as an increased tendency for toxins to cross the gut barrier, which can promote further kidney injury
Because B12 deficiency (which is pretty common, actually) affects your brain, vision, skin, and energy levels
Kim, D., Langmead, B
Your pharmacist can often facilitate this quickly