This is one of the most common questions we receive, and the confusion is understandable - both medications contain the same active ingredient, semaglutide
Why the study is misleading - The GLP1 group was dominated by older drugs like liraglutide and dulaglutide - The newer, more effective agents (semaglutide and tirzepatide) were barely included - Surgical patients were healthier and more motivated by design/screening, while the GLP1 group had more comorbidities and worse adherence - Treatment timelines did not align, so the comparison was not apples-to-apples - Risks were softened: 7% of surgical patients experienced serious complications, and nearly 1 in 200 died within 90 days So while the paper makes surgery look superior, what it really shows is surgery at its best compared to GLP1s at their weakest
There is currently no established causal link between Wegovy (semaglutide) and peripheral neuropathy in the published medical literature or regulatory documentation
Conversely, as previously mentioned, a synthetic analogue (TM30338) of both PYY3-36 and PP, which acts as an agonist of both the Y2 and Y4 receptors, yielded very promising results as concerns early meal termination when administered once-a-day subcutaneously in obese human subjects
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Wilson Critical review of the manuscript for important intellectual content: Sahar Shekoohi, Alan D