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The peptides interaction with opioid systems creates interesting research opportunities for withdrawal syndrome studies
They make sense conceptually but need clinical trials to determine safety, dosage, timing and interactions
HUBERMAN: Inadvertently assume that peptides are all safe or innocuous or that they are potent enough to do certain things that we want, but that because they're not hormone therapies per se, that they are free of side effects and risk
doi: 10.1016/j.bbi.2012.06.006 65 WalshCMZainalNZMiddletonSJPaykelES
However, despite adequate protocols, methodological flaws such as lack of randomization, concealment of allocation, lack of blinded outcome evaluation, and high heterogeneity in the doses used in supplementation, as well as among the included studies, can compromise the level of evidence generated in this systematic review
