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J Clin Endocrinol Metab 93(6):21812187 Johnson KC, Bray GA, Cheskin LJ, Clark JM, Egan CM, Foreyt JP et al (2017) The effect of intentional weight loss on fracture risk in persons with diabetes: results from the Look AHEAD randomized clinical trial

10), with only minor adjustments to the substrate-binding site to alleviate a steric clash between the tropane moiety and F443 of TM10